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Huntington’s disease drug maker UniQure is seeking US Food and Drug Administration (FDA) approval for its gene therapy

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💥 Check out this insightful post from Business News 📖 📂 **Category**: 💡 **What You’ll Learn**: Thomas Fuller | SOPA Photos | Rocket Lite | Getty ImagesUniQure The company said Wednesday it plans to seek FDA approval for its experimental gene therapy for Huntington's disease, months after the agency's former leaders criticized the evidence supporting the application. UniQure said the US Food and Drug Administration announced at its recent meeting that a three-year analysis of a Phase 1/2 study would support accelerated approval of UniQure's gene therapy for Huntington's disease, a rare genetic disease that gradually destroys nerve cells in…

The Competitive Moat That AI Can’t Replicate

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🚀 Discover this awesome post from Hacker News 📖 📂 **Category**: 💡 **What You’ll Learn**: The Restaurant That Refused to Take Bookings OnlineLet me tell you a story about a restaurant owner who became obsessed with human connection.He didn’t want people booking online. He wanted them to call. He wanted the ritual of a human voice, the small exchange about an anniversary or a first date, the warmth of being recognised. His team thought he was losing his mind. Online bookings were standard. Everyone did it. Why make customers work harder?One of the managers finally asked him a pointed question:…

CarMax (KMX) Q1 earnings

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✨ Explore this must-read post from Business News 📖 📂 **Category**: 📌 **What You’ll Learn**: A view of a CarMax dealership on April 10, 2025 in Santa Rosa, California.Justin Sullivan | Getty Imagesshares Carmax It fell nearly 8% during midday trading on Wednesday after the company beat Wall Street's quarterly earnings expectations and its new CEO detailed a high-profile turnaround strategy for the company.Here's how the company performed in its fiscal first quarter, compared to average estimates compiled by LSEG:EPS: $1.31 versus 95 cents expected profit: $8.01 billion versus $7.42 billion expectedDespite the volatility, questions remain about the company's ability…

Only 16 percent of Americans think AI will have a positive impact on society, a new study shows

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💥 Discover this must-read post from Hacker News 📖 📂 **Category**: ✅ **What You’ll Learn**: Despite the fact that AI increasingly dominates our economy (it’s hot IPO summer and we’re all just along for the ride), most Americans are not particularly optimistic about the technology’s long term impact on the country, a new study from Pew Research reveals. In fact, although a whole lot of Americans increasingly use AI in their daily lives, most of them have neutral to negative views about it, the research reveals. Only 16% of Americans think that AI’s impact on society during the next 20…

JetBlue is reducing its Newark and LaGuardia footprint as it expands into Florida

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✨ Check out this trending post from Business News 📖 📂 **Category**: 📌 **What You’ll Learn**: A JetBlue Airways plane lands near the air traffic control tower at Fort Lauderdale-Hollywood International Airport on October 7, 2025 in Fort Lauderdale, Florida.Joe Rydell | Getty ImagesJetBlue Airlines It told CNBC on Wednesday that it will close its flight attendant base at Newark Liberty International Airport in New Jersey and technical operations bases there and at LaGuardia Airport in New York this fall as it seeks to cut costs and boost service in Florida, though it noted that no employees would lose their…

Adam-CAD/CADAM: CADAM is the open source text-to-CAD web application · GitHub

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🚀 Discover this must-read post from Hacker News 📖 📂 **Category**: 💡 **What You’ll Learn**: 👉 adam.new/cadam. Generate a CAD model in seconds, right in your browser. No install required. 🤖 AI-Powered Generation - Transform natural language and images into 3D models 🎛️ Parametric Controls - Interactive sliders for instant dimension adjustments 📦 Multiple Export Formats - Export as .STL, .SCAD, or .DXF files 🌐 Browser-Based - Runs entirely in your browser using WebAssembly 📚 Library Support - Includes BOSL, BOSL2, and MCAD libraries Feature Description Natural Language Input Describe your 3D model in plain English Image References Upload images…

Target, Walmart, and Amazon lose out on LGBTQ+ consumer spending

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✨ Discover this insightful post from Business News 📖 📂 **Category**: 💡 **What You’ll Learn**: LGBTQ+ consumers are shifting their brand loyalties based on companies' diversity, equity and inclusion policies, according to new research from the Human Rights Campaign Foundation. Results released Wednesday found that nearly 72% of LGBTQ+ consumers say they buy fewer products from companies they see “Limiting Diversity and Inclusion Commitments.” Nearly 70% also said they had refused to buy from those companies at least some of the time.The five companies that participants most often associated with spending cuts were: goal, Walmart, AmazonChick-fil-A and Home Depot.On the…

Pentagon boasts of using AI to write reports mandated by Congress

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💥 Read this must-read post from Hacker News 📖 📂 **Category**: ✅ **What You’ll Learn**: It’s unclear what processes the Pentagon has in place to review the accuracy of its AI-generated reports to Congress. But such reports are a crucial element of congressional oversight intended to hold the US military accountable for how it uses taxpayer dollars—and so any AI-induced errors or mischaracterizations could undermine the accountability mechanism of such reports. This also comes at a time when the Pentagon has requested an unprecedented $1.5 trillion budget for the 2027 fiscal year. Members of the US military have also been…

5 takeaways from the largest annual gathering of airline CEOs

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🔥 Check out this insightful post from Business News 📖 📂 **Category**: 📌 **What You’ll Learn**: Ground crews load cargo and supplies onto planes from airlines including Lufthansa Group, Emirates, Austrian Airlines and British Airways, as they stand at the Tom Bradley International Terminal (TBIT) at Los Angeles International Airport (LAX) in El Segundo, California, on September 11, 2023.Patrick T. Fallon | AFP | Getty ImagesRIO DE JANEIRO — Hundreds of airline leaders gathered in Brazil this week at the International Air Transport Association's annual meeting to discuss high fuel costs, sharply low profits, engine reliability issues and elusive emissions…

AI demands more engineering discipline. Not less

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🚀 Check out this must-read post from Hacker News 📖 📂 **Category**: 💡 **What You’ll Learn**: A few days back I wrote a piece called “AI enthusiasts are in a race against time, AI skeptics are in a race against entropy.” I have notes on a whole pile of AI-related topics that I’d like to cover in depth: AI mandates, communication norms, code review, AI art, and more. Unfortunately, I got too many interesting responses to my last piece, and now I have to address those before I can move on to other topics. 😉There were two types of interesting…