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The Isomorphic Labs Drug Design Engine unlocks a new frontier beyond AlphaFold

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🔥 Discover this trending post from Hacker News 📖 📂 **Category**: ✅ **What You’ll Learn**: We are giving a glimpse at a subset of the powerful and expansive capabilities of the Isomorphic Labs Drug Design Engine (IsoDDE), a unified computational drug-design system, progressing beyond AlphaFold 3 (AF3) in its predictive accuracy and introducing new capabilities which bridge the gap between structure prediction and real-world drug discovery. We demonstrate that our IsoDDE more than doubles the accuracy of AlphaFold 3 on a challenging protein-ligand structure prediction generalisation benchmark, predicts small molecule binding-affinities with accuracies that exceed gold-standard physics-based methods at a fraction…

Loathe Review: A Stranger to You – Metalcore masters deliver stylistic deviations and surprising beauty | music

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🔥 Explore this awesome post from Culture | The Guardian 📖 📂 **Category**: Music,Metal,Pop and rock,Culture ✅ **What You’ll Learn**: toIt took the division six years to produce this fourth album, making it clear that they wanted to make it very special. Accordingly, A Stranger to You ventures far beyond Liverpudlians' core metal origins to create an odyssey of mixed and colliding genres. Punitive riffs and industrial noise slabs coexist with balm-like electronics, acoustic guitars, shoegaze, tinkling jazz piano, and spoken word narrations by guest rapper Bucky Sugar (“Forward Movement, Forever”). Other guests include singer Ollie Appleyard of Leeds rock…

Product Engineer [Assignment mandatory] at DrDroid

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🔥 Read this awesome post from Hacker News 📖 📂 **Category**: ✅ **What You’ll Learn**: ₹1.7M - ₹2.1M INR•0.01% - 0.10%•Bengaluru, KA, IN / Bengaluru, Karnataka, INRoleEngineering, Full stackVisaUS citizenship/visa not requiredSkillsJavaScript, Python, TypeScriptWhat we do DrDroid is building AI Agents for Platform & Infrastructure teams. We help engineering teams fix issues faster and reduce escalations during on-call—automating triage, debugging, and remediation. We’re also the team behind several open-source projects: 🔹 Playbooks – A runbook automation platform 🔹 Kenobi – An event analytics platform for debugging data pipelines Join us in redefining how teams run operations in the post-GPT world.…

‘I’m not interested in leather at all!’: John Wood talks about his own photography of Glasgow’s gay venues, and comparisons with Robert Mapplethorpe | Photography

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💥 Read this insightful post from Culture | The Guardian 📖 📂 **Category**: Photography,Art and design,Culture,Exhibitions,Glasgow,Sexuality,LGBTQ+ rights 📌 **What You’ll Learn**: WWhat is the story behind John Wood's photographs? Some may guess that his photographs, which depict male subjects in various states of undress, often wearing black leather jackets, gloves and boots, were taken in New York in the era of BDSM photographer Robert Mapplethorpe and Studio 54. Or perhaps they were created in very A different kind of darkroom – the kind of space that inspired the proverbial images of artist Tom of Finland? If I gave you a…

I started a “dirt notebook” – PINEWIND

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💥 Explore this insightful post from Hacker News 📖 📂 **Category**: 💡 **What You’ll Learn**: I started a "dirt notebook" – PINEWIND Home Blog Now Shelf 13 Jul, 2026 I love taking notes, but one problem that I have is that that I start cherishing every notebook that I start. I can't seem to keep my notes messy. Eventually, I start structuring the notes, doing cleaner handwriting, adding a cover or some stickers ... and before I know it, the notebook is too well-organised for simply scribbling into. This, of course, raises the hurdle for taking more notes and makes…

‘It’s a Spiritual Experience’: The docuseries centers on the incredible mayhem of Burning Man | documentary

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💥 Explore this awesome post from Culture | The Guardian 📖 📂 **Category**: Documentary,Burning Man festival,Festivals,Culture,Factual TV,HBO 💡 **What You’ll Learn**: IIn 1986, a group of starving artists seeking release amid a devastating economic recession built an oversized wooden sculpture, transported it to a San Francisco beach and set it on fire while police officers and passersby looked on in disbelief. Forty years later, Burning Man is the festival to end all festivals—a sprawling spectacle of music, art, and self-expression that draws tens of thousands to the Nevada desert each summer for community, catharsis, and spiritual connection. It's a pilgrimage…

Your Credit Card Points Are a Transfer From the Broke to the Comfortable

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🔥 Explore this insightful post from Hacker News 📖 📂 **Category**: 📌 **What You’ll Learn**: Credit card rewards aren’t free money. They’re funded by interest paid at an average 25.2% APR, mostly by the roughly half of cardholders who carry a balance, plus over $30 billion a year in fees, plus swipe fees baked into the price of nearly everything you buy. In 2023, Federal Reserve researchers published a paper on just this topic. They found that about $15.1 billion a year flows from less sophisticated cardholders to more sophisticated ones. From less educated to more educated. From poorer zip…

I Can Die Too review – Vibrant pop songs can’t bring the actor’s story to life | stage

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💥 Explore this must-read post from Culture | The Guardian 📖 📂 **Category**: Theatre,Pitlochry Festival theatre,Stage,Culture,Musicals 📌 **What You’ll Learn**: IIf Frances Ruffell wanted to put on a one-woman cabaret show, that would be very good. The West End and Broadway star has certainly put together a good collection of original songs to embody 'I Could Die Too'.Written by dozens of songwriters and brightly arranged by musical director Fro, it has the vibe of 80s and 90s pop like Cyndi Lauper, Britney Spears and Ultravox. A touch of torch song here, a slice of synth ballad there. Backed by cello,…

Attorney General Ken Paxton Secures Landmark Legal Victory to Lock Pornographic Website Domain and Protect Minors From Harmful Content

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✨ Explore this must-read post from Hacker News 📖 📂 **Category**: ✅ **What You’ll Learn**: Attorney General Ken Paxton secured a landmark court order to cut off a pornographic website’s ability to operate under its domain name after the company failed to take measures to protect children from the harmful sexual content it published. This legal victory establishes a significant precedent for enforcing age-verification laws against non-compliant foreign operators.In April 2024, Attorney General Paxton sued Kick Online Entertainment (“Kick”), the owner of the pornographic website motherless.com, for violating Texas’s age-verification law. He subsequently obtained a Default Judgment and Permanent Injunction…

First Night of Prom Review – 250th Anniversary of US Independence Takes Center Stage | Concerts 2026

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🔥 Discover this trending post from Culture | The Guardian 📖 📂 **Category**: Proms 2026,Classical music,BBC Symphony Orchestra,Music,Culture,Proms,UK news 💡 **What You’ll Learn**: AAnd we are back. The world's greatest classical music festival has opened the doors of the Royal Albert Hall for another eight-week season. While the last night of concerts is often strangely disconnected – a self-contained concert for a very different audience – the first night is the celebration for those who are here for the long haul, the maker of the scene and the season in microcosm. So what will this year say?Whatever the current geopolitical…