Wales v South Africa: Tom Rogers subbed off as Tandy forced to make 12 substitutions

Six players – full-back Blair Murray, fly-half Dan Edwards, scrum-half Kieran Hardie, hooker and captain Dewi Leake, tighthead prop Kieron Asserati, and back-row forward Alex Mann – will feature in their fourth tests of the autumn.

The loss of Rogers and Bristol’s Louis Rees-Zammit means that Ellis Mee, who was called up to the squad on Monday, and Rio Dyer have been selected on the wings.

Center Joe Roberts and scrum-half Kieran Hardie come in to replace Gloucester pair Max Llewellyn and Tomos Williams.

Gareth Thomas gets his first start of the autumn in a loose position, while there is a new partnership in the second row between Ben Carter and Rhys Davies.

Ospreys lock James Fender has been denied the chance to win the first game due to a shoulder injury.

The return of Wainwright means Alex Mann moves to the openside at the expense of Harri Deaves with Taine Plumtree shifting to the blindside.

Cardiff loosehead Danny Southworth is set to make his Test debut from a bench that also includes club teammate Callum Sheedy.

Ten players were prepared for their first match of the autumn – Mee, Roberts, Dyer, Carter and Davies in the XV and Southworth, Chris Coleman, lock James Rattie, scrum-half Robin Morgan-Williams and Sheedy on the bench.

“What we want to see from the boys is the same kind of effort and performance we had last weekend,” Tandy said.

“I think we showed a lot of intent offensively, and a lot of solidity in the way we went about it with a lot of defensive efforts as well, to give the fans something to shout about.”